An integrative computational analysis gives evidence for FBN1-connected community deregulation in trisomy 21 [Investigation Article]

On August 19, 2013, Posted by , In BIO, tagged in ,,,,,,,,,, , With Comments Off on An integrative computational analysis gives evidence for FBN1-connected community deregulation in trisomy 21 [Investigation Article]

Mireia Vilardellone,*, Sergi Civit2 and Ralf Herwig1 1Division of Vertebrate Genomics, Max-Planck-Institute for Molecular Genetics, Ihnestrasse 63–73, D-14195 Berlin, Germany twoOffice of Data, College of Barcelona, Avenida Diagonal 645, Barcelona, 08028, Spain ↵*Author for correspondence (nogalesatmolgen.mpg.de) Summary Although around fifty% of Down Syndrome (DS) clients have coronary heart abnormalities, they…

Evidence from a germ plasm in the milkweed bug Oncopeltus fasciatus, a hemimetabolous insect [Investigation Post]

On July 12, 2013, Posted by , In BIO, tagged in ,,,,,,,,,, , With Comments Off on Evidence from a germ plasm in the milkweed bug Oncopeltus fasciatus, a hemimetabolous insect [Investigation Post]

Summary Primordial germ mobile (PGC) development in holometabolous insects like Drosophila melanogaster relies on maternally synthesised germ cell determinants that are asymmetrically localised to the oocyte posterior cortex. Embryonic nuclei that inherit this “germ plasm” acquire PGC fate. In contrast, historic research of basally branching bugs (Hemimetabola) advise that a…