The Mitotic Exit Network: new turns on aged pathways

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The Mitotic Exit Network: new turns on aged pathways

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The Mitotic Exit Community: new turns on aged pathways

Developments in Cell Biology,
Publication Date 28 October 2013
Copyright © 2013 All legal rights reserved.
DOI: 10.1016/j.tcb.2013.09.010

Manuel Hotz

Yves Barral

Institute of Biochemistry, Biology Section, ETH Zurich, Schafmattstrasse eighteen, 8093 Zurich, Switzerland

Recent address: Section of Biology, Stanford College, Stanford, CA, United states of america

Summary

In budding yeast, the Mitotic Exit Community (Gentlemen) is a signaling pathway acknowledged to drive cells out of mitosis and market the trustworthy division of cells. The Men triggers inactivation of cyclin-dependent kinase (Cdk1), the grasp regulator of mitosis, and the onset of cytokinesis right after segregation of the daughter nuclei. The present model of the Males indicates that Men activity is limited to late anaphase and coordinated with correct alignment of the spindle pole bodies (SPBs) with the division axis. However, recent proof suggests that Males action may possibly function before in mitosis, prompting re-analysis of the present design. Listed here we endeavor to integrate this current progress into the recent view of mitotic exit.

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