FancJ regulates interstrand crosslinker induced centrosome amplification by means of the activation of polo-like kinase 1 [Analysis Report]
- Jianqiu Zou,
- Fen Tian,
- Ji Li,
- Wyatt Pickner,
- Molly Lengthy,
- Khosrow Rezvani,
- Hongmin Wang and
- Dong Zhang*
Basic Biomedical Science Division, Sanford School of Drugs, College of South Dakota, Vermillion, South Dakota, 57069, United states of america
- ↵*Writer for correspondence ( )
DNA damage response (DDR) and the centrosome cycle are two of the most critical procedures for keeping a stable genome
in animals. Sporadic proof indicates a relationship in between these two procedures. Right here, we report our findings that six Fanconi
Anemia (FA) proteins, including FancI and FancJ, localize to the centrosome. Intriguingly, we found that the localization
of FancJ to the mother centrosome is stimulated by a DNA interstrand crosslinker, Mitomycin C (MMC). We further show that,
in addition to its role in interstrand crosslinking (ICL) restore, FancJ also regulates the standard centrosome cycle as nicely
as ICL induced centrosome amplification by activating the polo-like kinase 1 (PLK1). We have uncovered a novel perform of
FancJ in centrosome biogenesis and established centrosome amplification as an integral portion of the ICL response.
- Obtained June 14, 2013.
- Acknowledged July three, 2013.
- © 2013. Printed by The Organization of Biologists Ltd
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