Tethering the assembly of SNARE complexes

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Tethering the assembly of SNARE complexes

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Tethering the assembly of SNARE complexes

Traits in Cell Biology,
Publication Date ten October 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2013.09.006

WanJin Hong

Sima Lev

College of Pharmaceutical Sciences, Xiamen College, Xiamen, People’s Republic of China

Institute of Molecular and Mobile Biology, Singapore

Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot 76100, Israel


The fusion of transport vesicles with their target membranes is essential for intracellular membrane trafficking and various physiological procedures and is driven by the assembly of useful soluble N-ethylmaleimide-delicate element attachment protein receptor (SNARE) complexes. Prior to fusion, transportation vesicles are physically linked to their target membranes by different tethering aspects. Recent research advise that tethering aspects also positively regulate the assembly of functional SNARE complexes, therefore coupling tethering with fusion activities. This coupling is mediated, at least in element, by direct physical interactions among tethering aspects, SNAREs, and Sec1/Munc18 (SM) proteins. In this evaluation we summarize current progress in comprehending the roles of tethering elements in the assembly of specific and functional SNARE complexes driving membrane-fusion occasions.

Trends IN Cell BIOLOGY

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