Immune synapse: conductor of orchestrated organelle movement

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Immune synapse: conductor of orchestrated organelle movement

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Immune synapse: conductor of orchestrated organelle motion

Trends in Cell Biology,
Publication Date 10 Oct 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2013.09.005

Noa Beatriz Martín-Cófreces

Francesc Baixauli

Francisco Sánchez-Madrid

Servicio de Inmunología, Clinic Universitario de la Princesa, UAM, IIS-IP, Madrid, Spain

Department of Vascular Biology and Irritation, Fundación Centro Nacional de Investigaciones Cardiovasculares-Carlos III, Madrid, Spain

Summary

To ensure suitable mobile purpose, intracellular organelles are not randomly distributed inside the mobile, but polarized and hugely constrained by the cytoskeleton and associated adaptor proteins. This partnership in between distribution and operate was at first located in neurons and epithelial cells however, recent evidence suggests that it is a basic phenomenon occurring in many highly specialized cells like T lymphocytes. Recent studies expose that the orchestrated redistribution of organelles is dependent on antigen-specific activation of and immune synapse (IS) formation by T cells. This assessment highlights the practical implications of organelle polarization in early T cell activation and examines recent results on how the IS sets the rhythm of organelle movement and the unfold of the activation sign to the nucleus.

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