HIV trafficking in host cells: motors desired!
HIV trafficking in host cells: motors needed!
Trends in Cell Biology,
Publication Day 10 Oct 2013
Copyright © 2013 Elsevier Ltd All legal rights reserved.
Bruna Cunha de Alencar
Institut Curie, Centre de Recherche, 26 rue d’Ulm, 75248 Paris Cedex 05, France
INSERM, U932, 26 rue d’Ulm, 75248 Paris Cedex 05, France
INSERM, U941, Hôpital Saint Louis, one avenue Claude Vellefaux, 75010 Paris, France
Present tackle: Section of Cell Biology, Harvard Healthcare College and Program in Mobile and Molecular Medicine at Children’s Healthcare facility, two hundred Longwood Avenue, Boston, MA 02215, Usa.
Through the viral replication cycle, viral proteins, complexes, and particles want to be transported inside of host cells. These transportation occasions are dependent on the host cell cytoskeleton and molecular motors. Nevertheless, the mechanisms by which virus is trafficked along cytoskeleton filaments and how molecular motors are recruited and controlled to ensure successful integration of the viral genome and creation of new viruses has only just lately begun to be recognized. Recent reports on HIV have determined specific molecular motors concerned in the trafficking of these viral particles. Listed here we overview current literature on the transportation of HIV parts in the cell, give proof for the id and role of molecular motors in this approach, and spotlight how these trafficking activities could be connected to these transpiring with other viruses.