Microenvironmental regulation of most cancers metastasis by miRNAs
Microenvironmental regulation of cancer metastasis by miRNAs
Trends in Cell Biology,
Publication Date twelve Oct 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
Section of Pharmacology and Most cancers Biology, Duke University Health care Center, Durham, NC 27710, Usa
Essential Laboratory of An infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
miRNAs are a class of tiny, non-coding RNAs that control most cancers progression, especially the processes of invasion and metastasis. Although previously reports in metastasis mostly centered on the influence that miRNAs have on the intrinsic properties of most cancers cells, current studies reveal that miRNAs also shape interactions in between most cancers cells and their connected stroma. In this assessment, we discuss existing recognized mechanisms by which miRNAs execute their microenvironmental regulation of cancer metastasis, including regulating expression of cell membrane-sure and secreted proteins or right transmitting experienced miRNAs amongst different mobile sorts. The importance of miRNA-mediated tumor–stroma interactions in regulating metastasis implies that miRNAs could be a likely therapeutic concentrate on.