Obtaining rid of DNA methylation
Receiving rid of DNA methylation
Tendencies in Cell Biology,
Publication Day ten Oct 2013
Copyright © 2013 Elsevier Ltd All legal rights reserved.
Francesco M. Piccolo
Amanda G. Fisher
Lymphocyte Growth Team, MRC Scientific Sciences Centre, Imperial Higher education, Hammersmith Hospital Campus, Du Cane Highway, London W12 0NN, Uk
Methylation of cytosine in DNA is associated with transcriptional repression and genome surveillance. In vegetation and animals, conserved pathways exist to build and sustain this epigenetic mark. Mechanisms underlining its elimination are, nonetheless, assorted and controversial and can count on DNA synthesis (passive) or be unbiased of it (energetic). Ten–eleven translocation (Tet)-mediated conversion of five-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) has recently been evoked as a possible system in the initiation of active and passive DNA demethylation. This assessment discuses the latest progress in this thrilling area.