Exiting the ER: what we know and what we really don’t

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Exiting the ER: what we know and what we really don’t

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Exiting the ER: what we know and what we really don’t

Developments in Mobile Biology,
Publication Date 27 September 2013
Copyright © 2013 Elsevier Ltd All legal rights reserved.
DOI: 10.1016/j.tcb.2013.08.005

Rossella Venditti

Cathal Wilson

Maria Antonietta De Matteis

Telethon Institute of Genetics and Medication, Via Pietro Castellino 111, Naples 80131, Italy

Summary

The vast vast majority of proteins that are transported to diverse cellular compartments and secreted from the cell demand coat protein complex II (COPII) for export from the endoplasmic reticulum (ER). Many of the molecular mechanisms underlying COPII assembly are recognized in wonderful depth, but it is turning into more and more apparent that this fundamental equipment is inadequate to account for varied factors of protein export from the ER that are observed in vivo. Below we assessment latest data that have furthered our mechanistic comprehension of COPII assembly and, in specific, how genetic conditions associated with the early secretory pathway have additional basic insights into the regulation of ER-derived provider development. We also spotlight some unresolved issues that foreseeable future operate need to address to much better recognize the physiology of COPII-mediated transport.

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