Modifying appetites: the adaptive rewards of fuel selection

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Modifying appetites: the adaptive rewards of fuel selection

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Changing appetites: the adaptive rewards of gasoline choice

Trends in Cell Biology,
Publication Date 09 September 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
DOI: ten.1016/j.tcb.2013.07.010

Illana A. Stanley

Sofia M. Ribeiro

Alfredo Giménez-Cassina

Erik Norberg

Nika N. Danial

Office of Cancer Biology, Dana-Farber Most cancers Institute, Boston, MA 02115, United states

Department of Cell Biology, Harvard Health care Faculty, Boston, MA 02115, Usa

Institute for Interdisciplinary Investigation (IIIUC), University of Coimbra, Portugal

PhD Programme in Experimental Biology and Biomedicine (PDBEB), CNC – Middle for Neuroscience and Mobile Biology, College of Coimbra, Portugal

These authors contributed equally to this work.


Cells are able of metabolizing a range of carbon substrates, including glucose, fatty acids, ketone bodies, and amino acids. Mobile fuel option not only fulfills particular biosynthetic demands, but also permits programmatic variations to stress problems past compensating for alterations in nutrient availability. Emerging proof indicates that certain switches from utilization of one substrate to another can have protecting or permissive roles in condition pathogenesis. Knowing the molecular determinants of cellular gas preference may provide insights into the homeostatic control of pressure responses, and unveil therapeutic targets. Right here, we emphasize overarching themes encompassing cellular fuel option its url to mobile destiny and operate its benefits in tension security and its contribution to metabolic dependencies and maladaptations in pathological problems.

Tendencies IN Cell BIOLOGY

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