The Hippo pathway acts by way of p53 and microRNAs to management proliferation and proapoptotic gene expression in the course of tissue development [Analysis Post]
1Institute of Molecular Cell Biology, sixty one Biopolis Drive, Singapore 138673
twoDivision of Organic Sciences, Countrywide College of Singapore, fourteen Science Travel 4, Singapore 117543
- Authors for correspondence ( )
The Hippo pathway has a central position in coordinating tissue progress and apoptosis. Mutations that compromise Hippo pathway
action trigger tissue overgrowth and have been causally linked to most cancers. In Drosophila, the transcriptional coactivator Yorkie mediates Hippo pathway exercise to handle the expression of cyclin E and Myc to
market mobile proliferation, as well as the expression of bantam miRNA and DIAP1 to inhibit mobile dying. Listed here we existing evidence that the Hippo pathway functions by way of Yorkie and p53 to manage
the expression of the proapoptotic gene reaper. Yorkie more mediates reaper stages publish-transcriptionally via regulation of associates of the miR-2 microRNA family members to avoid apoptosis. These results
provide evidence that the Hippo pathway functions by way of numerous distinctive routes to restrict proliferation-induced apoptosis.
- Acquired February 3, 2013.
- Approved Might twenty, 2013.
- © 2013. Released by The Business of Biologists Ltd
This is an Open Entry report dispersed beneath the conditions of the Imaginative Commons Attribution License (http://creativecommons.org/licenses/by/3.), which permits unrestricted use, distribution and replica in any medium provided that the unique perform is properly