Genome researchers at Bielefeld University decode the hamster genome
The genome sequencing started out with the Chinese hamster (image). Genome researchers from Bielefeld University’s Middle for Biotechnology (CeBiTec) headed by Professor Dr. Alfred Pühler have succeeded in sequencing the genome of the Chinese hamster. The Chinese hamster materials the cell cultures used by the pharmaceutical industry to generate biopharmaceutical items these kinds of as antibodies utilized in drugs. This pricey project was only attainable thanks to a cooperation in between Bielefeld College and its global venture associates. The researchers have now released their final results in the internationally renowned scientific journal ‘Mother nature Biotechnology‘.
To carry out this undertaking, the CeBiTec study group cooperated with the University of Organic Assets and Daily life Sciences in Vienna (exactly where the undertaking was headed by Professor Dr. Nicole Borth), the Austrian Centre of Industrial Biotechnology (acib), and two pharmaceutical businesses: Novartis (in Switzerland) and Pfizer (in the Usa).
Professor Dr. Thomas Noll, Scientific Director of CeBiTec, is assured that the data they have acquired will be of excellent desire to science and sector. ‘In potential, the decoded hamster genome will drastically advance the use of mobile traces to generate pharmaceuticals’, says Noll, who operates the Cell Lifestyle Engineering study group at the College of Technology and participated in the study project.
The genome of the Chinese hamster is composed of eleven pairs of chromosomes. Decoding this kind of a massive genome calls for the generation of massive datasets that then have to be processed with bioinformatics. To facilitate the resulting knowledge evaluation, the scientists in Bielefeld and their colleagues in this venture utilized a completely new process that types the single chromosomes of the genome. The sequencing of the hamster chromosomes was done by Dr. Karina Brinkrolf at CeBiTec. More than one.4 billion quick DNA sequences have been generated with the assist of present day instruments for subsequent-era sequencing. ‘The key challenge in this undertaking was subsequently piecing these quick DNA sequences with each other to sort one complete sequences of chromosomes’, clarifies the head of the task Professor Alfred Pühler. This work can only be done with potent personal computers. ‘We had to full the new CeBiTec pc cluster and utilize new computer software before we could establish the genome sequence’, suggests the bioinformatics professional Dr. Alexander Goesmann who also worked on the task. ‘By decoding the hamster genome sequence’, notes Goesmann, ‘bioinformatics at Bielefeld College has broken new floor.’ With roughly two.three billion bases, the magnitude of the genome sequence of the Chinese hamster is similar to that of the human genome.
The head of the project Alfred Pühler views this study as a milestone in the work at CeBiTec: ‘The decoding of the hamster genome effectively concludes a key CeBiTec task. The hamster sequence is obtainable in the community domain and can be utilised for investigation during the entire world.’ The task drastically boosts the status of Bielefeld as a foundation for present study on the mobile cultures of the Chinese hamster, says Pühler. A further project has presently been agreed with the College of Normal Assets and Daily life Sciences in Vienna and the Austrian Centre of Industrial Biotechnology. ‘This spots Bielefeld College in a great place to carry on contributing to this highly aggressive discipline of research.’
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