Range of mobile dying pathways: insight from the fly ovary

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Range of mobile dying pathways: insight from the fly ovary

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Diversity of mobile loss of life pathways: insight from the fly ovary

Traits in Mobile Biology,
Publication Date 20 August 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2013.07.005

Victoria K. Jenkins

Allison K. Timmons

Kimberly McCall

Section of Biology, Boston College, 5 Cummington Shopping mall, Boston, MA, United states of america

Summary

Multiple varieties of cell loss of life exist including necrosis, apoptosis, and autophagic mobile dying. The Drosophila ovary gives a valuable product to study the diversity of mobile death modalities, and we assessment modern development to elucidate these pathways. At least five distinct varieties of mobile death take place in the ovary, and we focus on two that have been examined thoroughly. Mobile dying of mid-phase egg chambers takes place by way of a novel caspase-dependent pathway that involves autophagy and triggers phagocytosis by bordering somatic epithelial cells. For every single egg, fifteen germline nurse cells bear developmental programmed cell demise, which happens independently of most acknowledged mobile loss of life genes. These forms of cell dying are strikingly related to mobile loss of life observed in the germlines of other organisms.

Trends IN Cell BIOLOGY

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