LAR-RPTPs: synaptic adhesion molecules that condition synapse advancement

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LAR-RPTPs: synaptic adhesion molecules that condition synapse advancement

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LAR-RPTPs: synaptic adhesion molecules that condition synapse advancement

Developments in Mobile Biology,
Publication Day 05 August 2013
Copyright © 2013 All legal rights reserved.
DOI: 10.1016/j.tcb.2013.07.004

Ji Won Um

Jaewon Ko

Department of Biochemistry, College of Daily life Science and Biotechnology, Yonsei College, Seoul one hundred twenty-749, Korea

Summary

The synapse is the most elementary functioning unit in neurons, producing neural circuits that underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse connections, advertise their stabilization and refinement, and manage prolonged-term synaptic plasticity. Leukocyte widespread antigen-connected receptor protein tyrosine phosphatases (LAR-RPTPs) have earlier been implicated as crucial elements in central nervous program (CNS) development. Current scientific studies have demonstrated that LAR-RPTP household users are also associated in various synaptic capabilities, enjoying a position in synaptic adhesion pathways with each other with a host of distinct transmembrane proteins and serving as significant synaptic adhesion molecules in governing pre- and postsynaptic growth, dysfunctions of which could underlie different ailments. This review highlights the rising function of LAR-RPTPs as synapse organizers in orchestrating synapse advancement.

Trends IN Cell BIOLOGY

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