Concealing mobile defects in pluripotent stem cells
Concealing mobile problems in pluripotent stem cells
Tendencies in Mobile Biology,
Publication Day 01 August 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
Juan Carlos Izpisua Belmonte
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Street, La Jolla, CA 92037, United states
Condition key Laboratory of Drug Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Beijing Institute for Mind Issues, Beijing, China
Centre for Regenerative Drugs in Barcelona, Dr Aiguader 88, 08003 Barcelona, Spain
Core Facility for Protein Research, Chinese Academy of Sciences, Beijing, China
Inherent and acquired flaws in gene expression, protein homeostasis, metabolic pathways, and organelle function are linked to getting older and a broad selection of human ailments. Though concealed or dormant in the embryonic phase, they usually manifest later in lifestyle. We assessment and examine recent observations on how somatic cells bearing distinct phenotypic problems can be reprogrammed into a pluripotent condition exactly where most phenotypic abnormalities can be reset or tolerated. Gaining insights into the tolerance of cellular defects in pluripotent stem cells will aid our comprehension of the homes of reprogrammed cells and may possibly provide theoretical assistance for induced pluripotent stem mobile dependent disease modeling and clinical therapies.