DNA in motion in the course of double-strand split mend

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DNA in motion in the course of double-strand split mend

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DNA in movement for the duration of double-strand break fix

Trends in Mobile Biology,
Publication Day 16 July 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
DOI: ten.1016/j.tcb.2013.05.006

Judith Miné-Hattab

Rodney Rothstein

Institut de Biologie de l’Ecole Normale Supérieure (IBENS), CNRS UMR 8197, Ecole Normale Supérieure, 46, rue d’Ulm, 75005 Paris, France

Office of Genetics &amp Improvement, Columbia University Health-related Heart, New York, NY 10032, United states of america

Summary

DNA group and dynamics profoundly have an effect on numerous biological procedures such as gene regulation and DNA fix. In this review, we existing the latest scientific studies on DNA mobility in the context of DNA harm. Modern studies show that DNA mobility is substantially improved in the presence of double-strand breaks (DSBs) in the yeast Saccharomyces cerevisiae. As a consequence, chromosomes explore a greater nuclear volume, facilitating homologous pairing but also escalating the price of ectopic recombination. Increased DNA dynamics is dependent on several homologous recombination (HR) proteins and we are just commencing to realize how chromosome dynamics is controlled soon after DNA damage.

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