Retromer-mediated endosomal protein sorting: all WASHed up!

Home  >>  BIO  >>  Retromer-mediated endosomal protein sorting: all WASHed up!

Retromer-mediated endosomal protein sorting: all WASHed up!

On July 10, 2013, Posted by , In BIO, By ,,,, , With Comments Off on Retromer-mediated endosomal protein sorting: all WASHed up!

  
To look at the full text, remember to login as a subscribed person or buy a subscription. Simply click here to look at the complete text on ScienceDirect.

Retromer-mediated endosomal protein sorting: all WASHed up!

Tendencies in Cell Biology,
Publication Date 28 Could 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2013.04.010

Matthew N.J. Seaman

Alexis Gautreau

Daniel D. Billadeau

Cambridge Institute for Healthcare Study, Wellcome Have faith in/MRC Developing, Addenbrooke’s Healthcare facility, Cambridge CB2 0XY, British isles

Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette, France

Department of Immunology and Biochemistry, Division of Oncology Study, Mayo Clinic, Rochester, MN 55905, United states

All a few authors contributed equally to this operate.

Summary

Endosomal protein sorting governs the fate of a lot of physiologically crucial proteins concerned in a panoply of cellular functions. Recent discoveries have exposed a important part for endosomally localised branched actin patches in facilitating protein sorting. The development of the actin patches has been shown to require the operate of the Wash complicated – the significant endosomal actin polymerisation-promoting sophisticated – which stimulates the exercise of the ubiquitously expressed Arp2/3 sophisticated. An additional key part of the endosomal protein-sorting machinery is the retromer intricate. Studies now display that retromer mediates the recruitment of the Clean sophisticated and its regulators to endosomes. In this review, modern progress in understanding the role of the Wash sophisticated alongside with retromer in endosomal protein sorting is mentioned.

Traits IN Mobile BIOLOGY

Comments are closed.