Greasing the synaptic vesicle cycle by membrane lipids

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Greasing the synaptic vesicle cycle by membrane lipids

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Greasing the synaptic vesicle cycle by membrane lipids

Traits in Mobile Biology,
Publication Day ten June 2013
Copyright © 2013 Elsevier Ltd All legal rights reserved.
DOI: 10.1016/j.tcb.2013.05.002

Dmytro Puchkov

Volker Haucke

Leibniz Institut für Molekulare Pharmakologie (FMP), Robert-Roessle-Strasse ten, 13125 Berlin, Germany

Neurocure Cluster of Excellence, Freie Universität and Charité Universitätsmedizin Berlin, CCO, Rudolf-Virchowweg six, 10117 Berlin, Germany

Summary

Neurotransmission is dependent on the exocytic launch of neurotransmitters from synaptic vesicles (SVs) at nerve terminals and the subsequent retrieval of SV membranes. Evidence from genetic analysis of product organisms, large-resolution imaging, and biochemical studies show that, in addition to the properly-analyzed function of exo-endocytic protein networks, membrane lipids and their derivatives engage in a crucial part in SV cycling. These contain structural lipids these kinds of as cholesterol and sphingolipids as well as phosphoinositides (PIs), which interact with pick elements of the exocytic and endocytic machineries, thus coupling the two limbs of the SV cycle. Below we give an overview of the operate of lipids in SV cycling and discuss prospective versions of how lipids and lipid–protein interactions may control presynaptic operate.

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